Open positions

Position: Technical Assistant (MTA/BTA/CTA) (m/f/d)

We are seeking a motivated Technical Assistant to support the ERC project “BEYOND STRESS – The stress granule machinery controls metabolic signaling through mTOR at steady-state”.

Your tasks:

Planning and execution of experiments within the framework of the ERC project “BEYOND STRESS – The stress granule machinery controls metabolic signaling through mTOR at steady-state”

- - Participation in scientific publications
  - Education and training
  - Laboratory organisation

Your profile:

- - Completed training as Medical-Technical Assistant (MTA) / Biological-Technical Assistant (BTA) / Chemical-Technical Assistant (CTA)
  - Technical expertise in biochemistry and/or tumor/cell biology
  - Desired methodological abilities:
    Protein biochemistry (e.g., Immunoblot, EILSA, chromatography)
    Molecular biology (e.g,. Cloning, qPCR, RNAseq)
    Cell culture of cell lines (S1 and S2), transfection techniques, viability and proliferation assays, FACS
    Use of CRISPR/Cas9 systems (cloning, transduction, characterization on gDNA, mRNA, and protein level)
    Fluorescence microscopy
    Sample preparation and data processing for mass spectrometry-based proteomics and/or metabolomics
    Experience with mass spectrometric measurements (LC-MS, including both untargeted and targeted measurements using MRM) of proteins/peptides (proteomics), or metabolites (metabolomics), as well as data analysis and statistics, is beneficial
  - Fluency in English in writing and speaking
  - Strong communication skills
  - Motivation, teamwork, and self-organisational

For more details and to apply, please visit our job portal.

Position: PhD Student

We are seeking PhD candidates for upcoming third party funded projects. These positions will be published in the coming days. Stay tuned!

Interested in Joining Us?

Didn’t find the right position, but passionate about joining our team? We encourage you to reach out! Please contact Prof. Thedieck and include:
– Your project proposal
– How you envision integrating your research into our department

We are happy to support applications for third-party funded fellowships.

We also welcome enthusiastic undergraduate (pre-BSc and MSc) students seeking internship opportunities in our lab.

Email: Kathrin.Thedieck@uk-essen.de.

What we offer

As a member of the Department for “Metabolism, Senescence and Autophagy” at the Research Center One Health Ruhr, you will complement and strengthen our focus on metabolic signal transduction. Of particular interest is the interplay of oncogenic signalling cascades with tumour metabolism for the development of new predictive markers and therapeutic targets in preclinical models and clinical studies. Our excellence is highlighted by prestigous National and European grants including the ERC Advanced Grant BEYOND STRESS

Our method portfolio focuses on the biochemical and cell biological analysis of new mechanisms and the systems analysis of signalling and metabolic networks. Quantitative MS analysis of the proteome and metabolome and systems modelling go hand in hand. The department offers excellent instrumentation with the latest equipment technology for molecular & cell biology, biochemistry and MS-based proteo-metabolomics.

The newly founded Research Centre One Health Ruhr – from Molecules to Systems of the Universities of Duisburg-Essen, Dortmund and Bochum focuses on research into the fundamental mechanisms of health and disease, from the molecular level to higher-level systems. The ecosystem is the context in which we consider the complex interactions between environmental health, animal health and human health in the sense of the “One Health” concept. The “Metabolism, Senescence and Autophagy” department is particularly concerned with the influence of metabolic disruptors on oncogenic mechanisms and therapy response.

The Faculty of Medicine enjoys an excellent reputation – in the clinical and translational fields as well as in basic research. The key research areas “Oncology”, “Cardiovascular Diseases”, “Immunology and Infectiology”, “Translational Neuro- and Behavioural Sciences” and “Transplantation” are internationally established. We offer an excellent scientific environment and attractive opportunities for collaboration with renowned international, national and regional partners. As a site of the German Consortium for Translational Cancer Research (DKTK ) and the National Centre for Tumour Research (NCT), we offer a network of excellent partners in cancer research.