As a member of the newly founded department for “Metabolism, Senescence and Autophagy” (Head: Prof. Dr. rer. nat. Kathrin Thedieck) at the Research Center One Health Ruhr, the position holder will complement and strengthen the department’s focus on metabolic signal transduction (www.metabolic-signaling.eu). Of particular interest is the interplay of oncogenic signalling cascades with tumour metabolism for the development of new predictive markers and therapeutic targets in preclinical models and clinical studies. Methods focus on the biochemical and cell biological analysis of new mechanisms and the systems analysis of signalling and metabolic networks. Quantitative MS analysis of the proteome and metabolome and system modelling go hand in hand. The department offers excellent instrumentation with the latest equipment technology for molecular & cell biology, biochemistry and MS-based proteo-metabolomics.

The newly founded Research Centre One Health Ruhr – from Molecules to Systems of the Universities of Duisburg-Essen, Dortmund and Bochum focuses on research into the fundamental mechanisms of health and disease, from the molecular level to higher-level systems. The ecosystem is the context in which we consider the complex interactions between environmental health, animal health and human health in the sense of the “One Health” concept. The “Metabolism, Senescence and Autophagy” department is particularly concerned with the influence of metabolic disruptors on oncogenic mechanisms and therapy response.

The Faculty of Medicine enjoys an excellent reputation – in the clinical and translational fields as well as in basic research. The key research areas “Oncology”, “Cardiovascular Diseases”, “Immunology and Infectiology”, “Translational Neuro- and Behavioural Sciences” and “Transplantation” are internationally established. We offer an excellent scientific environment and attractive opportunities for collaboration with renowned international, national and regional partners. As a site of the German Consortium for Translational Cancer Research (DKTK) and the National Centre for Tumour Research (NCT), we offer a network of excellent partners in cancer research.