Publications

2017

Differential control of ageing and lifespan by isoforms and splice variants across the mTOR network.
Razquin Navas P, Thedieck K.
Essays Biochem. 2017 Jul 11;61(3):349-368. doi: 10.1042/EBC20160086.

Oncogenic β-catenin and PIK3CA instruct network states and cancer phenotypes in intestinal organoids.
Riemer P, Rydenfelt M, Marks M, van Eunen K, Thedieck K, Herrmann BG, Blüthgen N, Sers C, Morkel M.
J Cell Biol. 2017 Apr 25. doi: 10.1083/jcb.201610058.

PLK1 (polo like kinase 1) inhibits MTOR complex 1 and promotes autophagy.
Ruf S, Heberle AM, Langelaar-Makkinje M, Gelino S, Wilkinson D, Gerbeth C, Schwarz JJ, Holzwarth B, Warscheid B, Meisinger C, van Vugt MA, Baumeister R, Hansen M, Thedieck K.
Autophagy. 2017 Jan 19:0. doi: 10.1080/15548627.2016.1263781


2016

Tumor-Intrinsic PD-L1 Signals Regulate Cell Growth, Pathogenesis, and Autophagy in Ovarian Cancer and Melanoma. 
 
Clark CA, Gupta HB, Sareddy G, Pandeswara S, Lao S, Yuan B, Drerup JM, Padron A, Conejo-Garcia J, Murthy K, Liu Y, Turk MJ, Thedieck K, Hurez V, Li R, Vadlamudi R, Curiel TJ.
Cancer Res. 2016 Dec 1;76(23):6964-6974.

A systems study reveals concurrent activation of AMPK and mTOR by amino acids.
Dalle Pezze P*, Ruf S*, Sonntag AG*, Langelaar-Makkinje M, Hall P, Heberle AM, Razquin Navas P, van Eunen K, Tölle RC, Schwarz JJ, Wiese H, Warscheid B, Deitersen J, Stork B, Fäßler E, Schäuble S, Hahn U, Horvatovich P, Shanley DP°, Thedieck K°.
Nat Commun. 2016 Nov 21;7:13254. doi: 10.1038/ncomms13254.


2015

Functional proteomics identifies acinus L as a direct insulin- and amino acid-dependent mTORC1 substrate.
Schwarz JJ*, Wiese H*, Toelle RC, Zarei M, Dengjel J, Warscheid B°, Thedieck K°.
Mol Cell Proteomics. 2015 Apr 23. pii:mcp.M114.045807

TSC1 activates TGF-β - Smad2/3 signaling in growth arrest and epithelial to mesenchymal transition.
Thien, A*, Prentzel, MT*, Holzwarth, B, Klaesener, K, Kuper, I, Boehlke C, Sonntag A G, Ruf S, Maerz L, Nitschke R, Grellscheid SN, Reth M, Walz G, Baumeister R, Neumann-Haefelin E° , Thedieck K°
Developmental Cell. 2015 Mar 9; 32 (5):617–630. doi: 10.1016/j.devcel.2015.01.026. PubMed PMID: 25727005
→ View also the comment "TSC1 strikes out on its own" Sci. Signal., 24 March 2015 Vol. 8, Issue 369, p. ec66 doi: 10.1126/scisignal.aab1622

Nutrigenomics: Toward a Cross-Disciplinary Understanding of Nutrient-Driven Networks in Health and Disease.
Heiland, I,  Thedieck, K
Journal for Metabolic Research, Clinical Nutrition, and Dietetics. 2015; 40 (02), 88-92

Molecular mechanisms of mTOR regulation by stress.  
Heberle AM, Prentzell MT, van Eunen K, Bakker BM, Grellescheid SN, Thedieck K
Molecular and Cellular Oncology. 2015; 2 (2). doi: 10.4161/23723548.2014.970489


2014

PI3K-p110-alpha-subtype signalling mediates survival, proliferation and neurogenesis of cortical progenitor cells via activation of mTORC2.
Wahane SD*, Hellbach N*, Prentzell MT*, Weise SC, Vezzali R, Kreutz C, Timmer J, Krieglstein K, Thedieck K°, Vogel T° .
J Neurochem. 2014 Jul;130(2):255-67. doi: 10.1111/jnc.12718. Epub 2014 May 3. PubMed PMID: 24645666.

T cell receptor-mediated activation is a potent inducer of macroautophagy in human CD8(+)CD28(+) T cells but not in CD8(+)CD28(-) T cells.
Arnold CR, Pritz T, Brunner S, Knabb C, Salvenmoser W, Holzwarth B, Thedieck K°, Grubeck-Loebenstein B °.
Exp Gerontol. 2014 Jun;54:75-83. doi: 10.1016/j.exger.2014.01.018. Epub 2014 Jan 24. PubMed PMID: 24468331.


2013

Inhibition of mTORC1 by Astrin and Stress Granules Prevents Apoptosis in Cancer Cells.
Thedieck K°, Holzwarth B, Prentzell MT, Boehlke C, Kläsener K, Ruf S, Sonntag AG, Maerz L, Grellscheid SN, Kremmer E, Nitschke R, Kuehn EW, Jonker JW, Groen AK, Reth M, Hall MN, Baumeister R.
Cell. 2013 Aug 15;154(4):859-874. doi: 10.1016/j.cell.2013.07.031. PubMed PMID: 23953116.
→ View also the comment "Astrin Maintains Balanced mTORC1 Signaling under Cellular Stress" Cancer Discovery October 2013 3; doi: 10.1158/2159-8290.CD-RW2013-191


2012

A dynamic network model of mTOR signaling reveals TSC-independent mTORC2 regulation.
Dalle Pezze P*, Sonntag AG*, Thien A, Prentzell MT, Gödel M, Fischer S, Neumann-Haefelin E, Huber TB, Baumeister R, Shanley DP°, Thedieck K°.
SCIENCE Signaling. 2012 Mar 27;5(217):ra25. doi: 10.1126/scisignal.2002469. PubMed PMID: 22457331.
→ View also the perspective "Deconvolution of mTORC2 "in Silico"

Response to Comment on "A Dynamic Network Model of mTOR Signaling Reveals TSC-Independent mTORC2 Regulation"
Dalle Pezze, P*, Sonntag, AG*, Shanley, DP°, Thedieck, K°
SCIENCE Signaling. 2012 Jul 10;5(232):lc4.
*This is a related yet independent publication in which we respond with new data to several questions regarding the above study, raised by Prof. B. D. Manning, Harvard University, Boston, US.

A modelling-experimental approach reveals insulin receptor substrate (IRS)-dependent regulation of adenosine monosphosphate-dependent kinase (AMPK) by insulin
Sonntag AG,* Dalle Pezze P*, Shanley DP°, Thedieck K°.
FEBS J. 2012 Sep;279(18):3314-28. doi: 10.1111/j.1742-4658.2012.08582.x. PubMed PMID: 22452783.


2006 - 2011

Bile proteomic profiles differentiate cholangiocarcinoma from primary sclerosing cholangitis and choledocholithiasis.
Lankisch TO, Metzger J, Negm AA, Vosskuhl K, Schiffer E, Siwy J, Weismüller TJ, Schneider AS, Thedieck K, Baumeister R, Zürbig P, Weissinger EM, Manns MP, Mischak H, Wedemeyer J.
Hepatology. 2011 Mar;53(3):875-84. doi: 10.1002/hep.24103. Epub 2011 Jan 3. PubMed PMID: 21374660

Translational Control by Amino Acids and Energy.
Thedieck, K and Hall, MN
The Handbook of Cell Signaling, R. Bradshaw and E. Dennis (editors), 2nd edition, 2009.

Proteins induced by telomere dysfunction and DNA damage represent biomarkers of human aging and disease.
Jiang H, Schiffer E, Song Z, Wang J, Zürbig P, Thedieck K, Moes S, Bantel H, Saal N, Jantos J, Brecht M, Jenö P, Hall MN, Hager K, Manns MP, Hecker H, Ganser A, Döhner K, Bartke A, Meissner C, Mischak H, Ju Z, Rudolph KL.
Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11299-304. doi: 10.1073/pnas.0801457105. PubMed PMID:18695223.

PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis.
Thedieck K*, Polak P*, Kim ML, Molle KD, Cohen A, Jenö P, Arrieumerlou C, Hall MN.
PLoS One. 2007 Nov 21;2(11):e1217. PubMed PMID: 18030348; PubMed Central

The MprF protein is required for lysinylation of phospholipids in listerial membranes and confers resistance to cationic antimicrobial peptides (CAMPs) on Listeria monocytogenes.
Thedieck K*, Hain T*, Mohamed W, Tindall BJ, Nimtz M, Chakraborty T, Wehland J, Jänsch L.
Mol Microbiol. 2006 Dec;62(5):1325-39. PubMed PMID: 17042784

*equally contributing     °corresponding author

Patents

Method for modeling, optimizing, parameterizing, testing and/or validating a dynamic network or network perturbation.
Thedieck K, Sonntag AG, Dalle Pezze P,  Shanley DP.
Priority date June 1 2011, Publication n° WO2012163440.

Modulators of the interaction of astrin and raptor, and uses thereof in cancer therapy.
Thedieck K, Holzwarth B, Baumeister R.
Priority date Jan. 11 2013, Publication n° WO2014108532.